After having Lyx on OSX fail to load PDF previews for the Nth time the thought occurs that relying on third party command line tools like ImageMagick and Ghostscript, or even sips (which I believe is the 'fix') is horribly fragile and there is a better way.
Why not integrate Pdfium into Lyx? It's open source with a non-restrictive license. Battle tested. You're never going to have issues with commands changing their name or not being in the PATH or whatever. Plus it opens up new opportunities, e.g. an integrated render preview, faster native resolution graphics previews, etc.