Thanks for everyone's comments.
 
With some big help from a perl expert the solution was found.
Sometime ago a folder /root/tmp was created and it looks like the problem took affect
when apache was restarted.
Perl 5 (which we have installed) looks for tmp folders to write to in a certain order and
was not able to and wanted to write to /root/tmp. The Perl module was changed
and the problem was solved. In Perl 6 it is stated that this feature, searching for a
tmp folder, was problematic and that it has been changed in Perl 6.

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