Then I'd say you ought to try making the load the callback of the post
and see if that works, something along the lines of:

$("#TOAppr").live("click", function() {
                $.post("webapps/hr/admin/actions/act_adminHR_handler.cfm", {
                                desc: $(this).attr('desc'),
                                pk: $(this).attr('pk')
                        },
                        function() {
                                
$("#content-box").load("webapps/hr/admin/display/dsp_timeOffApprove.cfm?dept="+dept+"&ap=1");
                        });
                return false;
        });

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