Brendon, in our environment, we use NFS for shared storage, we are
using APC as well with stat=0. In our setting, we are experiencing
high number of stat() calls on the NFS. My initial finding of this
problem is we enabled the open_basedir setting. And there is already a
bug report for this, https://bugs.php.net/bug.php?id=52312

We tested the issue in 5.2.x, 5.3.x and 5.4.x, all of them
experiencing same issue.

I m not sure if this is a same problem as yours. But I do hope the
community can find out a good solutions to handle the balance of
better security and good performance.

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