I saw that Guix includes OpenVR[1], which is kind of problematic, because there is no libre compatible runtime. I have a Valve Index, which I use without Steam[2], using the libre runtime Monado, which currently only supports OpenXR[3], but I plan to add a nonsteam OpenVR runtime to Monado. So I think there is no need to remove OpenVR. In Debian this packages is in contrib, because of the SteamVR dependency.
[1]https://guix.gnu.org/en/packages/openvr-1.8.19/ [2]https://www.gnu.org/philosophy/nonfree-games.html [3]https://guix.gnu.org/en/packages/openxr-1.0.24/