Alexandre Oliva writes: > Full-disk encryption (LUKS) is also a strict requirement for me, and so > is multi-disk BTRFS.
Note that full disk encryption does work without LVM in Guix, though you do need to then pretty much put everything on one partition :) I think you can also do full disk encryption from libreboot by decrypting the whole disk from GRUB. I forget how that works, though. Welcome to Guix, btw!