Hi Ludo, Success! I have been able to upgrade the root Guix installation.
The steps I have taken were: i) remove the 'latest' symlink ii) re-create the symlink to point to the previous installation iii) use 'guix gc --delete' to delete the guile-gcrypt package components iv) run 'GUILE_LOAD_PATH=/root/.guix-profile/share/guile/site/2.2 guix pull' v) run 'GUILE_LOAD_COMPILED_PATH=/gnu/store/3yvsd7w79a8rl42rxfg0xqzh9s14f3si- guile-gcrypt-0.1.0/lib/guile/2.2/site-ccache guix package --upgrade' This time the '... guix pull' command did not generate the ' Failed to autoload make-session in (gnutls)' errors. In retrospect, I think the only missing element from the first attempt was the GUILE_LOAD_PATH variable. The last piece of the jigsaw was setting GUILE_LOAD_COMPILED_PATH so that the gcrypt module could be found. This was required for all of the guix commands that I tried. Now: $ guix package --list-installed guix 0.15.0- 3.3d43017 out /gnu/store/sa9xj13i0568xajsjh78g3pnlsww8x8g- guix-0.15.0-3.3d43017 ... Best regards, Paul.