I've found this issue https://github.com/golang/go/issues/10303 which can 
answer my questions.

在 2019年3月21日星期四 UTC+8下午1:56:17,Cholerae Hu写道:
>
> package main
>
> // void a(long *p) {}
> import "C"
>
> import (
> "unsafe"
> )
>
> //go:noinline
> func b() {
> x := int64(0)
> C.a((*C.long)(unsafe.Pointer(&x)))
> // do something without x
> }
>
> func main() {
> b()
> }
>
> x should be considered unreachable after C.a . If x is something allocated 
> on heap, do I need to use runtime.KeepAlive(x) to make sure x will not be 
> garbage collected?
>

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