Peter, thank you it's very intresting survey. I'll try to investigate it carefully. I've looking for the same issue for along time it's also would be good to find more recent review on the same topic.
By the way today I've found that the testing on the receptor stability in the case of some point mutations might not be good with the unbiassed MD simulation. Some people told me that for most valid result the biased MD by the aplication of the external forces must be done. Finally even if i've done very 'deadly' mutation (e.g strong perturbation of the tight packing in the functional-relevant region of the transmembrane segment) this effect could not been seen even in the relatively long trajectory. By contract that publication wich you provide the different conditions were tested for the refirement of the X-ray result in the standart MD. So is there any compromise between both of the methods of the MD? James
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