I'm all in favour of requiring isl and enabling graphite by default, but would 
suggest to enable it with -Ofast instead. 

One reason is that certainly extracting testcases from a PGO build is more 
difficult, and initially there will certainly be miscompiles with graphite 
(CP2K is right now). 

Furthermore, unless graphite is particularly effective with PGO (does it use 
average loop trip counts already?), I don't see a particular connection.

Joost

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