"The IDEA of Smalltalk derived from the IDEA of Simula; the philosophy and 
ideas of Englebart, Bush, Sutherland; the metaphor of cellular biology, and 
undoubtedly more. Alan Kay coalesced those influences and led the team that 
implemented the team that actually created the language at Xerox PARC."

For example, I don't see analogs of cytokines, hormones, or neurotransmitters 
in Smalltalk or any computing systems today.    The closest that comes to mind 
are functional reactive programming systems, e.g. game platforms tied to a 
physics engine.   
The idea that top-down intent matters is preposterous if the motivation is 
biology, a massively-parallel bottom-up phenomena that involves physical stuff.

Marcus

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