Thanks, gentlemen. TJ On Jan 15, 2018 6:30 PM, "Roger Critchlow" <[email protected]> wrote:
> Tom -- > > The original twitter thread where I learned of the paper was > https://twitter.com/casa_tuthill/status/951902638571905024 and it > expressed a mixture of respect and jealousy for the groups reporting the > discovery. > > https://www.theatlantic.com/science/archive/2018/01/brain- > cells-can-share-information-using-a-gene-that-came-from-viruses/550403/ > might clarify, but it's still a bit abbreviated. > > Clearly, once they had isolated the gene, they would have found the family > resemblance to the retroviruses that they eventually used to identify the > ancestor gene, but that resemblance would have been more puzzling than > helpful. > > Searching twitter for "arc gene" generates an interesting list of tweets > about the discovery. > > -- rec -- > > On Mon, Jan 15, 2018 at 4:47 PM, Marcus Daniels <[email protected]> > wrote: > >> < That said, wouldn't it be grand if authors of papers like this would >> embed in the summary a link to a sidebar showing "Here's how we did this." >> i.e. how does one render "Purified Arc capsids"? > >> >> The Cell paper explains in terse "you should know this" language. I >> agree it would be nice if publishers would add value by providing link >> modes in the browser to reference not just prior work, but also textbook >> explanations for technical terms and techniques. That would make topics >> like this understandable to a larger (motivated) audience. Not every topic >> should expect a reader to unfold references back in time indefinitely. >> >> Marcus >> >> ------------------------------ >> *From:* Friam <[email protected]> on behalf of Tom Johnson < >> [email protected]> >> *Sent:* Monday, January 15, 2018 2:12:21 PM >> *To:* Friam@redfish. com >> *Subject:* Re: [FRIAM] Arc gene transports mRNA's across synapses >> >> Roger: >> I really appreciate your sending this along. That said, wouldn't it be >> grand if authors of papers like this would embed in the summary a link to a >> sidebar showing "Here's how we did this." i.e. how does one render "Purified >> Arc capsids"? >> TJ >> >> On Jan 15, 2018 12:19 PM, "Barry MacKichan" < >> [email protected]> wrote: >> >> Object-oriented programming in the cell, with encapsulated code! >> >> --Barry >> >> On 13 Jan 2018, at 17:47, Roger Critchlow wrote: >> >> In case you thought you understood the general molecular biology of life, >> here's another curve ball for you: >> >> http://www.cell.com/cell/fulltext/S0092-8674(17)31504-0 >> >> Summary >> >> The neuronal gene *Arc* is essential for long-lasting information >> storage in the mammalian brain, mediates various forms of synaptic >> plasticity, and has been implicated in neurodevelopmental disorders. >> However, little is known about Arc’s molecular function and evolutionary >> origins. Here, we show that Arc self-assembles into virus-like capsids that >> encapsulate RNA. Endogenous Arc protein is released from neurons in >> extracellular vesicles that mediate the transfer of *Arc* mRNA into new >> target cells, where it can undergo activity-dependent translation. Purified >> Arc capsids are endocytosed and are able to transfer *Arc* mRNA into the >> cytoplasm of neurons. These results show that Arc exhibits similar >> molecular properties to retroviral Gag proteins. Evolutionary analysis >> indicates that Arc is derived from a vertebrate lineage of Ty3/*gypsy* >> retrotransposons, >> which are also ancestors to retroviruses. These findings suggest that Gag >> retroelements have been repurposed during evolution to mediate >> intercellular communication in the nervous system. >> -- rec -- >> >> ============================================================ >> FRIAM Applied Complexity Group listserv >> Meets Fridays 9a-11:30 at cafe at St. John's College >> to unsubscribe http://redfish.com/mailman/listinfo/friam_redfish.com >> FRIAM-COMIC http://friam-comic.blogspot.com/ by Dr. Strangelove >> >> >> ============================================================ >> FRIAM Applied Complexity Group listserv >> Meets Fridays 9a-11:30 at cafe at St. John's College >> to unsubscribe http://redfish.com/mailman/listinfo/friam_redfish.com >> FRIAM-COMIC http://friam-comic.blogspot.com/ by Dr. Strangelove >> >> >> ============================================================ >> FRIAM Applied Complexity Group listserv >> Meets Fridays 9a-11:30 at cafe at St. John's College >> to unsubscribe http://redfish.com/mailman/listinfo/friam_redfish.com >> FRIAM-COMIC http://friam-comic.blogspot.com/ by Dr. Strangelove >> > > > ============================================================ > FRIAM Applied Complexity Group listserv > Meets Fridays 9a-11:30 at cafe at St. John's College > to unsubscribe http://redfish.com/mailman/listinfo/friam_redfish.com > FRIAM-COMIC http://friam-comic.blogspot.com/ by Dr. Strangelove >
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