External Email - Use Caution        

Thank you so much Martin.


This is super and very much appreciated. I'll try this and resample all my data 
and then hopefully it will run successfully through the longitudinal pipeline 
over my three time points.


Best regards and again thank you for your reply.


Cheers


Erik

________________________________
From: freesurfer-boun...@nmr.mgh.harvard.edu 
<freesurfer-boun...@nmr.mgh.harvard.edu> on behalf of Martin Reuter 
<mreu...@nmr.mgh.harvard.edu>
Sent: 04 July 2018 16:32:41
To: Freesurfer support list
Subject: Re: [Freesurfer] Longitudinal errors, Voxel size differs

Hi Erik,

better late then never:
you should use mri_convert --conform input output



Best, Martin



Erik O'Hanlon
Postdoctoral researcher

[cid:rcsi-crest-signature_f581c185-1d03-45c8-a786-23d8ece3d391.png]

RCSI Psychiatry
Royal College of Surgeons in Ireland
Beaumont Road, Beaumont D9 Ireland
T: 8093740
E: erikohan...@rcsi.ie W: www.rcsi.com<http://www.rcsi.com/>


Transforming Healthcare Education, Research and Service: RCSI Strategic Plan 
2018-2022<http://www.rcsi.ie/strategy2018>


[cid:both3_b9da8717-e91f-4ea7-8729-dc2c4d0a7a5f.png]


On 16. May 2018, at 12:19, Erik O'Hanlon 
<erikohan...@rcsi.ie<mailto:erikohan...@rcsi.ie>> wrote:

        External Email - Use Caution

Thank Martin,

I've been looking into this and it appears that the slight changes in the 
sequence may have occurred software updates to the scanner. So essentially from 
what you say, this drastically impacts any longitudinal analyses as there will 
be a systematic bias across the data. Is there any point in trying to do 
longitudinal analyses with such data as it will be a factor in all output? Is 
it worth resampling all three time points to 1mm and then rerun the analysis as 
it will be difficult to say if any patterns of change arent due to the 
acquistions as you said?

If I want to resample the data to a "standard 1mm3" voxel size, is there a FS 
command for that or should I use something in FSL or AFNI tools and then feed 
the resampled data back to the recon-all inistial step in FS.

Thanks for the help and guidance. Much appreciated

Erik


________________________________
From: 
freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.harvard.edu>
 
<freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.harvard.edu>>
 on behalf of Martin Reuter 
<mreu...@nmr.mgh.harvard.edu<mailto:mreu...@nmr.mgh.harvard.edu>>
Sent: 15 May 2018 23:39
To: Freesurfer support list
Subject: Re: [Freesurfer] Longitudinal errors, Voxel size differs

Hi Erik,

you should investigate why this is the case. Any difference in acquisition will 
cause effects and it will be impossible to distinguish these from real effects.

Also you should never just resample one time point, as that will introduce 
processing bias. I would advise to
- find out why, and you need to report this in any analysis so that people are 
aware of this potential bias
- resample both time points to some 3rd space. Probably here simply conform 
them to 1mm isotropic.

Best, Martin


Erik O'Hanlon
Postdoctoral researcher
<rcsi-crest-signature_f581c185-1d03-45c8-a786-23d8ece3d391.png>
RCSI Psychiatry
Royal College of Surgeons in Ireland
Beaumont Road, Beaumont D9 Ireland
T: 8093740
E: erikohan...@rcsi.ie<mailto:erikohan...@rcsi.ie> W: 
www.rcsi.com<http://www.rcsi.com/>

Transforming Healthcare Education, Research and Service: RCSI Strategic Plan 
2018-2022<http://www.rcsi.ie/strategy2018>

RCSI DEVELOPING HEALTHCARE LEADERS
WHO MAKE A DIFFERENCE WORLDWIDE


<both3_b9da8717-e91f-4ea7-8729-dc2c4d0a7a5f.png>

On 15. May 2018, at 07:20, Erik O'Hanlon 
<erikohan...@rcsi.ie<mailto:erikohan...@rcsi.ie>> wrote:


Hi FS Experts,

I'm trying to run a longitudinal analysis across three timepoints and have run 
the cross steps for the data. I then ran the base step but found that my voxel 
dimensions are slightly different across the timepoints and I got the following 
error


ERROR: MultiRegistration::loadMovables: images have different voxel sizes.
  Currently not supported, maybe first make conform?
  Debug info: size(2) = 0.881117, 0.881117, 0.881117   size(0) = 0.884507, 
0.884507, 0.884507
MultiRegistration::loadMovables: voxel size is different 
/projects/pi-vokeane/HPC_16_00925/MC_FS_testdata_EOH/freesurfer/subjects/abd025_tp3/mri/norm.mgz.


I assume I need to resample the data to the voxel size of the first time point 
and then rerun. Can you advise on what command to use to resample the images 
from time 2 and time 3 to those of time 1 before rerunning from scratch. I 
assume I can't avoid rerunning the initial reconall step once I resample my 
data.

Any guidance is much appreciated

Best regards

Erik

Erik O'Hanlon
Postdoctoral researcher
<rcsi-crest-signature_f581c185-1d03-45c8-a786-23d8ece3d391.png>
RCSI Psychiatry
Royal College of Surgeons in Ireland
Beaumont Road, Beaumont D9 Ireland
T: 8093740
E: erikohan...@rcsi.ie<mailto:erikohan...@rcsi.ie> W: 
www.rcsi.com<http://www.rcsi.com/>

Transforming Healthcare Education, Research and Service: RCSI Strategic Plan 
2018-2022<http://www.rcsi.ie/strategy2018>

RCSI DEVELOPING HEALTHCARE LEADERS
WHO MAKE A DIFFERENCE WORLDWIDE


<both3_b9da8717-e91f-4ea7-8729-dc2c4d0a7a5f.png>

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