Hi doug and others,
Thanks doug.
I can understand multiple regression. However there is no obvious relationship 
between these two variables. So I try to test correlation between thickness and 
these two variables. If I try to consider all subjects as one group, and test 
correlation between this one group thickness and one variable, can I design 
matrix like this 
:http://surfer.nmr.mgh.harvard.edu/fswiki/Fsgdf1G1V#Contrast2.28slope.mtx.29 ?
Thanks.
All the best.
Rujing Zha

2014-02-25



charujing123



发件人:Douglas N Greve <gr...@nmr.mgh.harvard.edu>
发送时间:2014-02-25 00:25
主题:Re: [Freesurfer] fsgdf and contrasts
收件人:"charujing123"<charujing...@163.com>
抄送:"freesurfer@nmr.mgh.harvard.edu"<freesurfer@nmr.mgh.harvard.edu>

if you have multiple variables then you have to do multiple regression  
before testing the correlation 
doug 

On 02/21/2014 09:35 PM, charujing123 wrote: 
> Hi doug and others, 
> I want to perform correlation analysis,just one dependent variable and  
> one independent variable. Previously I think the contrast(i.e.0 0 0.5  
> 0.5 0 0) I design is for correlation between score1 and thickness. But  
> yestoday I found this information  
> http://surfer.nmr.mgh.harvard.edu/fswiki/Fsgdf2G2V#Contrast6g1g2.age.mtx.  
> It told me that "Null Hypothesis: does mean of group age slope differ  
> from 0? Is there anaverage affect of age regressing out the effect of  
> group and weight?". Regressing out the effect of group and weight  
> represents this contrast is for multimple regression,not simple  
> correlation between two varibles. I am confused. 
> Doug, would you please tell me where I am wrong? 
> Thanks. 
> All the best. 
> Rujing Zha. 
> 2014-02-22 
> ------------------------------------------------------------------------ 
> charujing123 
> ------------------------------------------------------------------------ 
> *发件人:*Douglas Greve <gr...@nmr.mgh.harvard.edu> 
> *发送时间:*2014-02-21 23:35 
> *主题:*Re: [Freesurfer] fsgdf and contrasts 
> *收件人:*"freesurfer"<freesurfer@nmr.mgh.harvard.edu> 
> *抄送:* 
> 
> I'm not sure I understand. Your contrasts below are fine. What are you  
> unsure about? 
> doug 
> 
> 
> 
> 
> On 2/20/14 7:48 PM, charujing123 wrote: 
>> Hidoug and others, 
>> Thanks doug. 
>> I see.If I want to implement multiple regression, i.e. two EVs(score1  
>> and score2) explain pial thickness, what contrast I should design for  
>> this. 
>> Thanks again. 
>> All the best. 
>> Rujing Zha 
>> 2014-02-21 
>> ------------------------------------------------------------------------ 
>> charujing123 
>> ------------------------------------------------------------------------ 
>> *发件人:*Douglas N Greve <gr...@nmr.mgh.harvard.edu> 
>> *发送时间:*2014-02-21 03:39 
>> *主题:*Re: [Freesurfer] fsgdf and contrasts 
>> *收件人:*"freesurfer"<freesurfer@nmr.mgh.harvard.edu> 
>> *抄送:* 
>> yes, they are, though you don't need to do the positive and negative 
>> contrasts because the sign is preserved 
>> doug 
>> On 02/20/2014 12:47 AM, charujing123 wrote: 
>> > Hi FS experts and users, 
>> > I am trying to implement independent sample t-test and correlation 
>> > analysis. 
>> > Here is my fsgdf design: 
>> > ----------------------------- 
>> > GroupDescriptorFile 1 
>> > Title lh_ttest 
>> > Class CON_IA 
>> > Class PAT_IA 
>> > Variables score1 score2 
>> > Input CON_IA01 CON_IA 0 0 
>> > Input CON_IA03 CON_IA 0 0 
>> > Input CON_IA05 CON_IA 0 0 
>> > Input CON_IA06 CON_IA 0 0 
>> > Input CON_IA07 CON_IA 3 7 
>> > Input CON_IA09 CON_IA 0 0 
>> > Input CON_IA14 CON_IA 0 0 
>> > Input CON_IA15 CON_IA 0 0 
>> > Input CON_IA16 CON_IA 7 12 
>> > Input CON_IA19 CON_IA 6 15 
>> > Input CON_IA24 CON_IA 6 11 
>> > Input CON_IA27 CON_IA 3 3 
>> > Input CON_IA32 CON_IA 7 21 
>> > Input CON_IA33 CON_IA 7 21 
>> > Input CON_IA35 CON_IA 0 0 
>> > Input CON_IA38 CON_IA 7 15 
>> > Input CON_IA39 CON_IA 2 3 
>> > Input CON_IA40 CON_IA 6 8 
>> > Input CON_IA41 CON_IA 2 4 
>> > Input PAT_IA01 PAT_IA 8 13 
>> > Input PAT_IA02 PAT_IA 9 38 
>> > Input PAT_IA03 PAT_IA 9 33 
>> > Input PAT_IA04 PAT_IA 9 27 
>> > Input PAT_IA06 PAT_IA 9 26 
>> > Input PAT_IA08 PAT_IA 8 16 
>> > Input PAT_IA09 PAT_IA 9 33 
>> > Input PAT_IA16 PAT_IA 9 35 
>> > Input PAT_IA18 PAT_IA 9 39 
>> > Input PAT_IA21 PAT_IA 9 32 
>> > Input PAT_IA22 PAT_IA 9 31 
>> > Input PAT_IA23 PAT_IA 9 35 
>> > Input PAT_IA24 PAT_IA 9 40 
>> > Input PAT_IA25 PAT_IA 9 29 
>> > Input PAT_IA27 PAT_IA 9 30 
>> > Input PAT_IA29 PAT_IA 9 30 
>> > Input PAT_IA30 PAT_IA 8 32 
>> > Input PAT_IA33 PAT_IA 9 13 
>> > Input PAT_IA34 PAT_IA 9 21 
>> > ------------------------------------------------ 
>> > Contrasts for independent sample t-test: 
>> > 1,CON_IA>PAT_IA:1 -1 0 0 0 0 
>> > 2,PAT_IA>CON_IA:-1 1 0 0 0 0 
>> > Contrasts for correlation analysis: 
>> > 1,possitive correlation analysis between pial thickness and score1:0 0 
>> > 0.5 0.5 0 0 
>> > 2,negtive correlation analysis between pial thickness and score1:0 0 
>> > -0.5 -0.5 0 0 
>> > 3,positive correlation analysis between pial thickness and score2:0 0 
>> > 0 0 0.5 0.5 
>> > 4,negtive correlation analysis between pial thickness and score2:0 0 0 
>> > 0 -0.5 -0.5 
>> > Are my designs appropriate? 
>> > If I want to implement regression analysis(i.e. dependent variable is 
>> > thickness and independent variables are score1 and score2), how to 
>> > design my contrast? 
>> > Thanks. 
>> > All the best. 
>> > Rujing Zha 
>> > 2014-02-20 
>> > ------------------------------------------------------------------------  
>> 
>> > charujing123 
>> > 
>> > 
>> > _______________________________________________ 
>> > Freesurfer mailing list 
>> > Freesurfer@nmr.mgh.harvard.edu 
>> > https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer 
>> --  
>> Douglas N. Greve, Ph.D. 
>> MGH-NMR Center 
>> gr...@nmr.mgh.harvard.edu 
>> Phone Number: 617-724-2358 
>> Fax: 617-726-7422 
>> Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting 
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>> The information in this e-mail is intended only for the person to whom it is 
>>  
>> 
>> addressed. If you believe this e-mail was sent to you in error and the 
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>> contains patient information, please contact the Partners Compliance 
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> 

--  
Douglas N. Greve, Ph.D. 
MGH-NMR Center 
gr...@nmr.mgh.harvard.edu 
Phone Number: 617-724-2358 
Fax: 617-726-7422 

Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting 
FileDrop: https://gate.nmr.mgh.harvard.edu/filedrop2 
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