Dear Experts,
I was wondering if you could possibly help me with a
reviewer-related question:
We conducted a between-group-analysis estimating the
interaction between cortical thickness and age.
In summary, we wanted
to investigate whether the interaction between cortical thickness and age is
stronger for one group relative to another (using a DODS design).
We cluster-corrected our results using a Monte Carlo cluster
correction of p<0.01 and attained significant group differences for several
areas over the left and right hemisphere.
One of the reviewer commented that although group
differences were estimated for each hemisphere separately, they ought to have
been cluster-corrected for both hemispheres.
Would you be able to tell me whether or not cluster-correcting
for both hemispheres is a necessity, or help me understand the possible
implications of not having cluster-corrected for both hemispheres?
Very Best Regards,
Catherine
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