Hello,
I was curious if anyone had specific recommendations for correcting ROIs
for total brain volume/ICV. From what I can tell, some groups correct each
ROI by computing a ratio of ROI/total_brain_volume. Other groups, however,
enter total brain volume as a covariate in their statistical models. Both
methods seem reasonable, but it seems entering total brain size as a
covariate may be more robust, controlling for potential interactions with
other IVs (e.g. age, gender). Are there other strategies I am missing?
Any advice is much appreciated!
Thanks!
-Ryan
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