For starters, how does such a solution work conceptually? The possibility of load-balancing appliances has been suggested; how does this work with user databases and uploaded files? Our services are primarily web-based and do involve a significant amount of users uploading files, and database (postgres) work.
For databases, you'll need to look into a RDMBS which supports parallelism and distributed transaction processing. Oracle will sell you something, albeit for a hefty price. :-)
For files, people using redundant multipath topology over fibre-channel, which allows several machines to access the same filestorage safely in parallel. I'm not sure there's much of the available for FreeBSD, but Apple just released their Xsan product based off the Xserve RAID boxes and various third-party fibre-channel switches.
-- -Chuck
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