I did some testing several years ago with ClamAV, Sophos and McAfee (scanning incoming mail), and ClamAV was comparable to McAfee in detection rates - over 98%.

i use clamav for mail virus checking and IMHO it is the only place where realtime virus checking make sense.

some windows users have NOD32 antivirus and i never got a case that NOD32 detected email virus after clamav filter.

Of course this is all windows only problem, unix doesn't have viruses.
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