I have just started scanning some Kodachromes with the SS120, with disastrous results. I had previously scanned them on an Epson 1640 (which I was using before the SS120) with default settings and got satisfactory, if not extraordinary, scans. With the SS120, I got horrible scans with Silverfast (despite IT-8 calibration) and passable scans with Insight. With Silverfast, the scans are so far off color-wise that it is virtually impossible to correct, while with Insight, I was able to get reasonably close with PS modifications. I have not had these types of problems with color negatives.
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