It looks like you may be looking for `org-mu4e-compose-org-mode'. Matt Price writes:
> I've just switched to mu4e. It's unbelievably great, thank you everyone > who's recommended it over the years. > > However, I would like to compose my replies in org-mode and send them out > as HTML. I guess the older tools for doing this are officially deprecated. > Nonetheless, does anyone use them? Would you be willing to share your > workflow, and thoughts about what pain points you still have?? I see John > K. has written some cool posts about, e.g., sending headings out, but not > about org-ifying the compose buffer. > > Thank you! > Matt