http://stackoverflow.com/questions/842831/using-sql-server-with-django-in-production

Might help. No personal experience though.

On 12 March 2010 12:16, Nick <nickt...@gmail.com> wrote:
> I am working on a new project that has a Microsoft SQL Server 2008 for
> storing data. Can I bind Python and Django with this DB? Are there any
> performance issues involved? What sort of server configuration needs
> to be done?
>
> This is for a job and so I can't really use something that's not been
> tested and is reliable.
>
> Thanks in advance for any responses.
>
> Nick
>
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