You could always create a responsive interface—e.g.: using
twitter-bootstrap—and then distribute it onto every platform.

Web (obviously): Django templates or "standard" web frontend—using
e.g.: REST, XMLRPC or JSONRPC—that calls functions and serialises data
in a less data heavy way (on clients' end)
Mobiles: Adobe's open-source PhoneGap
Desktops: Adobe Air, HTML Applications (Windows) and MacGap (OSX) are
all possibilities... however I would recommend checking out Nokia's
open-source Qt, and distributing your product with a renderer. In
essense, you would be distributing your own browser without your page
as homepage, and which can only access what you allow (e.g.:
*.mydomain.com/*). See their webkit-fancybrowser example for an idea
of how this could be done.

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