Hey Todd, I am working on a large web app with django and backward incompatibility issues shows up on my nightmares from time to time.
I would say start your app with the latest version of SVN and always keep it updated. On every SVN update read backward incompatible changes (http://code.djangoproject.com/wiki/BackwardsIncompatibleChanges), address them on spot and let your application evolve with it. Best of luck, Sia

