Below VR related issues currently open. Most of these issues did not exist in 4.5.x and are related to VR refactor (persistent VR).
Blocker https://issues.apache.org/jira/browse/CLOUDSTACK-8690 - Remote Access VPN not working Critical https://issues.apache.org/jira/browse/CLOUDSTACK-8688 - Default policy for INPUT and FORWARD chain is ACCEPT in VR filter table (Wilder is working on this) https://issues.apache.org/jira/browse/CLOUDSTACK-8681 - CS does not honor the default deny egress policy in isolated network https://issues.apache.org/jira/browse/CLOUDSTACK-8710 - site2site vpn iptables rules are not configured on VR https://issues.apache.org/jira/browse/CLOUDSTACK-8685 - Default route is not configured on VPC VR https://issues.apache.org/jira/browse/CLOUDSTACK-8694 - Monitor service cron job not visible