I don't know how this might help, but I followed the instructions to download 
and un-squash the version 102.0.1 of thunderbird to my home folder, cd'd into 
the squashfs-root folder and ran thunderbird using ./thunderbird -p which 
picked up my current profile from the ~/.thunderbird directory. 
>From another terminal window and within the same squashfs-root directory, I 
>can successfully run ./thunderbird --compose which then brings up a compose 
>window whilst thunderbird itself is still running.

Make sure that you make a backup of the ~/.thunderbird folder first,
running the latest version of thunderbird alters the profile.

Does this add further info to the problem?

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Packages, which is subscribed to thunderbird in Ubuntu.
https://bugs.launchpad.net/bugs/1980839

Title:
  thunderbird -compose returns error since the 102 snap update?

Status in thunderbird package in Ubuntu:
  New

Bug description:
  After updating to the latest thunderbird 102.0.1 snap on Ubuntu 20.04,
  it is no longer possible to open mailto links from the firefox snap in
  thunderbird. When clicking a mailto link in the firefox 102.0.1 snap,
  thunderbird returns the following error message: "Thunderbird is
  already running, but is not responding. To use Thunderbird, you must
  first close the existing Thunderbird process, restart your device, or
  use a different profile." The issue appears related to the thunderbird
  update as there was no issue opening links in the previous 91 version.

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