Please try to scan with hpaio Sane backend. It should help. The escl Sane backend, which you are currently using, is buggy and most of issue was resolved with next Sane version.
** Changed in: simple-scan (Ubuntu) Status: New => Incomplete -- You received this bug notification because you are a member of Desktop Packages, which is subscribed to simple-scan in Ubuntu. https://bugs.launchpad.net/bugs/1912952 Title: simple-scan SANE_STATUS_NO_MEM Status in simple-scan package in Ubuntu: Incomplete Bug description: Ubuntu 21.04: Start simple-scan, click on 'scan' I have a message 'Failed to scan - Unable to connect scanner' debug log says 'SANE_STATUS_NO_MEM' Same scanner works fine on Ubuntu 20.10 corrado@corrado-x6-hh-0122:~$ simple-scan --debug [+0,00s] DEBUG: simple-scan.vala:2012: Starting simple-scan 3.38.1, PID=3523 [+0,00s] DEBUG: unsetenv() is not thread-safe and should not be used after threads are created [+0,01s] DEBUG: _g_io_module_get_default: Found default implementation dconf (DConfSettingsBackend) for ‘gsettings-backend’ [+0,03s] DEBUG: app-window.vala:1990: Loading state from /home/corrado/.cache/simple-scan/state [+0,03s] DEBUG: app-window.vala:1969: Restoring window to 600x400 pixels [+0,07s] DEBUG: scanner.vala:1548: sane_init () -> SANE_STATUS_GOOD [+0,07s] DEBUG: scanner.vala:1554: SANE version 1.0.31 [+0,07s] DEBUG: scanner.vala:1615: Requesting redetection of scan devices [+0,07s] DEBUG: scanner.vala:828: Processing request [+0,44s] DEBUG: app-window.vala:2065: Saving state to /home/corrado/.cache/simple-scan/state [+7,68s] DEBUG: scanner.vala:341: sane_get_devices () -> SANE_STATUS_GOOD [+7,68s] DEBUG: scanner.vala:353: Device: name="escl:http://127.0.0.1:60000" vendor="HP" model="DeskJet 2600 series [665032] (USB)" type="flatbed scanner" [+7,68s] DEBUG: scanner.vala:353: Device: name="hpaio:/usb/DeskJet_2600_series?serial=CN0569B27006PS" vendor="Hewlett-Packard" model="DeskJet_2600_series" type="all-in-one" [+8,00s] DEBUG: app-window.vala:2065: Saving state to /home/corrado/.cache/simple-scan/state [+14,99s] DEBUG: simple-scan.vala:1817: Requesting scan at 75 dpi from device 'escl:http://127.0.0.1:60000' [+14,99s] DEBUG: scanner.vala:1683: Scanner.scan ("escl:http://127.0.0.1:60000", dpi=75, scan_mode=ScanMode.COLOR, depth=8, type=single, paper_width=0, paper_height=0, brightness=0, contrast=0, delay=3000ms) [+14,99s] DEBUG: scanner.vala:828: Processing request [+14,99s] DEBUG: scanner.vala:889: sane_open ("escl:http://127.0.0.1:60000") -> SANE_STATUS_NO_MEM [+14,99s] WARNING: scanner.vala:893: Unable to open device: Out of memory [+15,30s] DEBUG: app-window.vala:2065: Saving state to /home/corrado/.cache/simple-scan/state [+15,86s] DEBUG: app-window.vala:2065: Saving state to /home/corrado/.cache/simple-scan/state [+473,36s] DEBUG: app-window.vala:2065: Saving state to /home/corrado/.cache/simple-scan/state [+474,87s] DEBUG: autosave-manager.vala:201: Deleting autosave records [+474,87s] DEBUG: scanner.vala:1711: Stopping scan thread [+474,87s] DEBUG: scanner.vala:828: Processing request [+474,88s] DEBUG: scanner.vala:1722: sane_exit () corrado@corrado-x6-hh-0122:~$ corrado@corrado-x6-hh-0122:~$ inxi -SCMIx System: Host: corrado-x6-hh-0122 Kernel: 5.8.0-36-generic x86_64 bits: 64 compiler: gcc v: 10.2.1 Desktop: GNOME 3.38.2 Distro: Ubuntu 21.04 (Hirsute Hippo) Machine: Type: Desktop Mobo: ASRock model: H110M-G/M.2 serial: <superuser required> UEFI: American Megatrends v: P1.10 date: 05/11/2017 CPU: Info: Dual Core model: Intel Core i3-7100 bits: 64 type: MT MCP arch: Kaby Lake rev: 9 L2 cache: 3 MiB flags: avx avx2 lm nx pae sse sse2 sse3 sse4_1 sse4_2 ssse3 vmx bogomips: 31199 Speed: 800 MHz min/max: 800/3900 MHz Core speeds (MHz): 1: 800 2: 800 3: 800 4: 800 Info: Processes: 219 Uptime: 31m Memory: 7.48 GiB used: 1.73 GiB (23.1%) Init: systemd runlevel: 5 Compilers: gcc: N/A Packages: 1827 Shell: Bash v: 5.1.0 inxi: 3.2.02 corrado@corrado-x6-hh-0122:~$ ProblemType: Bug DistroRelease: Ubuntu 21.04 Package: simple-scan 3.38.1-1 ProcVersionSignature: Ubuntu 5.8.0-36.40+21.04.1-generic 5.8.18 Uname: Linux 5.8.0-36-generic x86_64 ApportVersion: 2.20.11-0ubuntu55 Architecture: amd64 CasperMD5CheckResult: skip CurrentDesktop: ubuntu:GNOME Date: Sun Jan 24 19:05:51 2021 InstallationDate: Installed on 2021-01-22 (2 days ago) InstallationMedia: Ubuntu 21.04 "Hirsute Hippo" - Alpha amd64 (20210122) MachineType: To Be Filled By O.E.M. To Be Filled By O.E.M. ProcKernelCmdLine: BOOT_IMAGE=/boot/vmlinuz-5.8.0-36-generic root=UUID=20c90aa4-17f1-4012-931a-04287724baba ro quiet splash vt.handoff=7 SimpleScanLog: SourcePackage: simple-scan UpgradeStatus: No upgrade log present (probably fresh install) dmi.bios.date: 05/11/2017 dmi.bios.release: 5.12 dmi.bios.vendor: American Megatrends Inc. dmi.bios.version: P1.10 dmi.board.name: H110M-G/M.2 dmi.board.vendor: ASRock dmi.chassis.asset.tag: To Be Filled By O.E.M. dmi.chassis.type: 3 dmi.chassis.vendor: To Be Filled By O.E.M. dmi.chassis.version: To Be Filled By O.E.M. dmi.modalias: dmi:bvnAmericanMegatrendsInc.:bvrP1.10:bd05/11/2017:br5.12:svnToBeFilledByO.E.M.:pnToBeFilledByO.E.M.:pvrToBeFilledByO.E.M.:rvnASRock:rnH110M-G/M.2:rvr:cvnToBeFilledByO.E.M.:ct3:cvrToBeFilledByO.E.M.: dmi.product.family: To Be Filled By O.E.M. dmi.product.name: To Be Filled By O.E.M. dmi.product.sku: To Be Filled By O.E.M. dmi.product.version: To Be Filled By O.E.M. dmi.sys.vendor: To Be Filled By O.E.M. 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