Same problem here, on boot:

sudo journalctl -xe

abr 03 04:06:25 Work dbus-daemon[1500]: [session uid=1000 pid=1500] 
Successfully activated service 'org.freedesktop.Notifications'
abr 03 04:06:25 Work systemd[1465]: Started XFCE notifications service.
-- Subject: Unit UNIT has finished start-up
-- Defined-By: systemd
-- Support: http://www.ubuntu.com/support
-- 
-- Unit UNIT has finished starting up.
-- 
-- The start-up result is RESULT.
abr 03 04:06:25 Work spice-vdagent[1742]: Cannot access vdagent virtio channel 
/dev/virtio-ports/com.redhat.spice.0
abr 03 04:06:25 Work dbus-daemon[1500]: [session uid=1000 pid=1500] Activating 
service name='ca.desrt.dconf' requested by ':1.48' (uid=1000 pid=1728 
comm="light
abr 03 04:06:25 Work dbus-daemon[1500]: [session uid=1000 pid=1500] 
Successfully activated service 'ca.desrt.dconf'
abr 03 04:06:25 Work dbus-daemon[824]: [system] Activating via systemd: service 
name='org.freedesktop.RealtimeKit1' unit='rtkit-daemon.service' requested by ':1
abr


cat /var/log/syslog* | grep -i spice-vdagent

Apr  3 04:05:59 Work ureadahead[311]: ureadahead:spice-vdagentd: Ignored 
relative path
Apr  3 04:05:59 Work ureadahead[311]: ureadahead:spice-vdagentd.target.wants: 
Ignored relative path
Apr  3 04:06:25 Work spice-vdagent[1742]: Cannot access vdagent virtio channel 
/dev/virtio-ports/com.redhat.spice.0
Apr  2 21:13:31 Work spice-vdagent[12780]: Cannot access vdagent virtio channel 
/dev/virtio-ports/com.redhat.spice.0


inxi -F

System:    Host: Work Kernel: 4.15.0-46-generic x86_64 bits: 64 Desktop: Xfce 
4.12.3 Distro: Ubuntu 18.04.2 LTS
Machine:   Device: desktop Mobo: ASRock model: B450M Pro4 serial: N/A
           UEFI [Legacy]: American Megatrends v: P1.10 date: 06/19/2018
CPU:       Quad core AMD Ryzen 5 2400G with Radeon Vega Graphics (-MT-MCP-) 
cache: 2048 KB
           clock speeds: max: 3600 MHz 1: 1653 MHz 2: 2062 MHz 3: 1646 MHz 4: 
1602 MHz 5: 1738 MHz 6: 1589 MHz
           7: 1669 MHz 8: 1609 MHz
Graphics:  Card: Advanced Micro Devices [AMD/ATI] Raven Ridge [Radeon Vega 
Series / Radeon Vega Mobile Series]
           Display Server: x11 (X.Org 1.19.6 ) drivers: ati,amdgpu (unloaded: 
modesetting,fbdev,vesa,radeon)
           Resolution: 1920x1080@59.93hz
           OpenGL: renderer: AMD RAVEN (DRM 3.23.0, 4.15.0-46-generic, LLVM 
7.0.0) version: 4.5 Mesa 18.2.8
Audio:     Card-1 Advanced Micro Devices [AMD] Device 15e3 driver: snd_hda_intel
           Card-2 Advanced Micro Devices [AMD/ATI] Device 15de driver: 
snd_hda_intel
           Sound: Advanced Linux Sound Architecture v: k4.15.0-46-generic
Network:   Card: Realtek RTL8111/8168/8411 PCI Express Gigabit Ethernet 
Controller driver: r8169
           IF: enp31s0 state: up speed: 1000 Mbps duplex: full mac: 
70:85:c2:a1:d0:f3

-- 
You received this bug notification because you are a member of Desktop
Packages, which is subscribed to spice-vdagent in Ubuntu.
https://bugs.launchpad.net/bugs/1800196

Title:
  spice-vdagent[1345]: Cannot access vdagent virtio channel /dev/virtio-
  ports/com.redhat.spice.0

Status in spice-vdagent package in Ubuntu:
  Confirmed

Bug description:
  Hello,

  $ journalctl -b

  [...]

  oct 26 07:26:57 romanescu spice-vdagent[1345]: Cannot access vdagent
  virtio channel /dev/virtio-ports/com.redhat.spice.0

  Best regards,
  --
  Cristian Aravena Romero (caravena)

  ProblemType: Bug
  DistroRelease: Ubuntu 18.10
  Package: spice-vdagent 0.17.0-1ubuntu2
  Uname: Linux 4.19.0-gnu x86_64
  ApportVersion: 2.20.10-0ubuntu13
  Architecture: amd64
  CurrentDesktop: ubuntu:GNOME
  Date: Fri Oct 26 14:34:00 2018
  InstallationDate: Installed on 2017-10-13 (378 days ago)
  InstallationMedia: Ubuntu 17.10 "Artful Aardvark" - Alpha amd64 (20170926)
  SourcePackage: spice-vdagent
  UpgradeStatus: No upgrade log present (probably fresh install)

To manage notifications about this bug go to:
https://bugs.launchpad.net/ubuntu/+source/spice-vdagent/+bug/1800196/+subscriptions

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