I had this on both firefox and thunderbird. The first time it happened a
reboot cured, but after a subsequent reboot it became permanent. It
turned out that something had removed the executable attribute from
~/.cache (no idea what or when). None of the other threads seem to have
suggested this, so I thought I should log it. Once you know where to
look it is easy to see and correct.

$ ls -l ~/.cache/
ls: cannot access /home/tony/.cache/rhythmbox: Permission denied
ls: cannot access /home/tony/.cache/telepathy: Permission denied
... (numerous similar errors) ...
ls: cannot access /home/tony/.cache/indicator-applet.log: Permission denied
ls: cannot access /home/tony/.cache/compizconfig-1: Permission denied
total 0
d????????? ? ? ? ?            ? checkbox/
d????????? ? ? ? ?            ? chromium/
... (numerous similar entries) ...
d????????? ? ? ? ?            ? winetricks/
d????????? ? ? ? ?            ? xine-lib/
$ ls -ld ~/.cache
drw------- 34 tony tony 4096 Mar 21 23:40 /home/tony/.cache/
$ chmod a+rwx ~/.cache
$ ls -ld ~/.cache
drwxrwxrwx 34 tony tony 4096 Mar 21 23:40 /home/tony/.cache/
$ ls -l ~/.cache/
total 164
drwxr-xr-x  3 tony tony  4096 Mar  7 00:06 checkbox/
drwx------  3 tony tony  4096 Jun 29  2013 chromium/
... (numerous similar entries) ...
drwxrwxr-x 18 tony tony  4096 Feb  2 22:44 winetricks/
drwx------  2 tony tony  4096 Mar 28 23:03 xine-lib/
$

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You received this bug notification because you are a member of Desktop
Packages, which is subscribed to firefox in Ubuntu.
https://bugs.launchpad.net/bugs/1033437

Title:
  Profile won't load. Ubuntu 12.10 amd64 daily.

Status in “firefox” package in Ubuntu:
  Confirmed

Bug description:
  when attempting to open firefox an error comes up saying "Your firefox
  profile cannot be loaded. it may be missing or inaccessible". i am
  running the daily build of ubuntu 64-bit in a virtual machine and
  other errors have come up.

To manage notifications about this bug go to:
https://bugs.launchpad.net/ubuntu/+source/firefox/+bug/1033437/+subscriptions

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