I have the same issue on a new Asus Zenbook prime UX31A-R4003P.

For me, it seems that the problem appears when I use VirtualBox.
Suddenly, the mouse click does not work anymore on the laptop screen but
it works on my external screen (HDMI one).

If I click <<Alt>> key as said by Andrey Sidorov, this solves the
problem.

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https://bugs.launchpad.net/bugs/1077805

Title:
  left click stops working after a while

Status in “xserver-xorg-input-synaptics” package in Ubuntu:
  Confirmed

Bug description:
  I did a clean install of Quantal a few days ago. I have a five year
  old Lenovo N100 3000 laptop. The install went smoothly and everything
  worked fine until later this evening. This started happening when
  playing scrabble on Facebook. The clicks would stop working. After a
  restart, it would work normally, but after an hour or so, it would
  stop working.

  I know this isn't a hardware issue, because I plugged in a USB mouse
  as well, and it had the same problem when the left click (and even
  right click on one occasion) wasn't working on my trackpad (tapping on
  the trackpad for left click stopped working too).

  How do I find out what's causing this, and more importantly, how do I
  fix it?

  P.S. I'll add an update in case it works fine if I don't use the
  Scrabble app.

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