I encountered this same issue in a freshly installed Ubuntu 18.04
system.

$ uname -a
Linux Machine 5.0.0-25-generic #26~18.04.1-Ubuntu SMP Thu Aug 1 13:51:02 UTC 
2019 x86_64 x86_64 x86_64 GNU/Linux

$ lsb_release -rd
Description:    Ubuntu 18.04.3 LTS
Release:        18.04

$ gnome-shell --version
GNOME Shell 3.28.4

To discover the error, I ran this app via command line:
$ /usr/bin/python3 /usr/bin/software-properties-gtk
ERROR:root:Authentication canceled, changes have not been saved
ERROR:root:Authentication canceled, changes have not been saved
ERROR:root:Authentication canceled, changes have not been saved
ERROR:root:Authentication canceled, changes have not been saved
ERROR:root:Authentication canceled, changes have not been saved
ERROR:root:Authentication canceled, changes have not been saved

The above errors appear every time the mouse arrow left-clicks on the
checkbox.

I circumvent this issue by:
1. left-click on Canonical Partners to select it.
2. left click on the edit button.
3. after the Edit Source GUI appeared, I left-clicked on the "OK" button.
4. finally when I left-click on the checkbox of Canonical Partners, the 
checkbox becomes selected.

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You received this bug notification because you are a member of Ubuntu
Desktop Bugs, which is subscribed to gnome-shell in Ubuntu.
https://bugs.launchpad.net/bugs/1727908

Title:
  Software & Updates application does not permit changes on the "Other
  Software" tab

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