I experienced the same problem under Ubuntu 14.04.5 when the system was under heavy computational load for an extended period of time (video encoding) There were no remote GVFS mounts as in atimonin case. I did not experience lagging as Valentis did.
What I tried and the results are as follows: 64bit:~$ killall nautilus 64bit:~$ nautilus -q Could not register the application: Timeout was reached 64bit:~$ killall nautilus 64bit:~$ nautilus Could not register the application: Timeout was reached 64bit:~$ nautilus -c running nautilus_self_check_file_utilities running nautilus_self_check_file_operations running nautilus_self_check_directory running nautilus_self_check_file running nautilus_self_check_canvas_container running nautilus_self_check_file_utilities running nautilus_self_check_file_operations running nautilus_self_check_directory running nautilus_self_check_file running nautilus_self_check_canvas_container gvfs-mount shows no remote mounts as seen below. 64bit:~$ gvfs-mount -l Drive(0): TOSHIBA THNSNH128GBST Type: GProxyDrive (GProxyVolumeMonitorUDisks2) Volume(0): 13 GB Volume Type: GProxyVolume (GProxyVolumeMonitorUDisks2) Drive(1): WDC WD2003FZEX-00Z4SA0 Type: GProxyDrive (GProxyVolumeMonitorUDisks2) Drive(2): WDC WD3001FAEX-00MJRA0 Type: GProxyDrive (GProxyVolumeMonitorUDisks2) Drive(3): Optiarc DVD RW AD-7280S Type: GProxyDrive (GProxyVolumeMonitorUDisks2) 64bit:~$ nautilus Could not register the application: Timeout was reached I was able to launch successfully via `gksu nautilus` -- You received this bug notification because you are a member of Ubuntu Desktop Bugs, which is subscribed to nautilus in Ubuntu. https://bugs.launchpad.net/bugs/1290310 Title: nautilus does not start To manage notifications about this bug go to: https://bugs.launchpad.net/ubuntu/+source/nautilus/+bug/1290310/+subscriptions -- desktop-bugs mailing list desktop-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/desktop-bugs