Hi Adrian, Last time for today :)
With the following configuration files it all works like I want it to: jeroen@debian:~$ cat /etc/NetworkManager/NetworkManager.conf [main] plugins=ifupdown,keyfile [ifupdown] managed=true [keyfile] unmanaged-devices=*,except:type:wifi,except:type:wwan,except:type:ethernet jeroen@debian:~$ cat /etc/network/interfaces # This file describes the network interfaces available on your system # and how to activate them. For more information, see interfaces(5). source /etc/network/interfaces.d/* # The loopback network interface auto lo iface lo inet loopback # The primary network interface #allow-hotplug enP2p36s15f0 #iface enP2p36s15f0 inet dhcp # This is an autoconfigured IPv6 interface #iface enP2p36s15f0 inet6 auto