Awesome!

Below, I'll comment on whatever I can meaningfully comment.

* Short term, you want to blacklist the ee1004 driver on your system.
   It is not a good idea to load a driver which binds to the wrong
   device.

Here we go, following https://wiki.debian.org/KernelModuleBlacklisting:

$ echo "blacklist ee1004" | sudo tee /etc/modprobe.d/ee1004.conf
blacklist ee1004
$ sudo depmod -ae
depmod: WARNING: -e needs -E or -F
$ sudo update-initramfs -u
update-initramfs: Generating /boot/initrd.img-6.12.107+deb13-amd64

Can the above warning be ignored?

* Still mid term, we probably want to blacklist SPD probing explicitly
   for your motherboard (we'll need to know the contents of
   /sys/devices/virtual/dmi/id/board_vendor and
   /sys/devices/virtual/dmi/id/board_name on your system). Maybe this
   can be implemented as an empty entry in mux_dmi_table (as in, we know
   the board requires multiplexing, but we don't know yet to implement
   it on that board).

Here we go:

$ cat /sys/devices/virtual/dmi/id/board_vendor
ASUSTeK COMPUTER INC.
$ cat /sys/devices/virtual/dmi/id/board_name
WS C422 PRO_SE

* Long term, we need the hardware vendor to provide technical
   information about the board so that we can implement SMBus
   multiplexing support in the i2c-i801 driver (if that's really how
   things are implemented on your board - that's only a guess from me at
   this point). Asus provided information about their Z8 series long ago
   and I was able to add support for it back then. It would be wonderful
   if they could provide similar information about the WS C422 PRO/SE so
   that a kernel developer can add support.


The user manuals for the board lie at 
https://www.asus.com/de/motherboards-components/motherboards/workstation/ws-c422-pro-se/helpdesk_manual?model2Name=WS-C422-PRO-SE
 .

As for anything deeper, it would be better if you, as a developer, contacted 
them directly. (In fact, the last time I actually succeeded in issuing a ticket 
was a long time ago, before the warranty ran out.) An ASUS support contact form 
lies at https://www.asus.com/support/product/contactus/services/questionform .

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