Awesome! Below, I'll comment on whatever I can meaningfully comment.
* Short term, you want to blacklist the ee1004 driver on your system. It is not a good idea to load a driver which binds to the wrong device.
Here we go, following https://wiki.debian.org/KernelModuleBlacklisting: $ echo "blacklist ee1004" | sudo tee /etc/modprobe.d/ee1004.conf blacklist ee1004 $ sudo depmod -ae depmod: WARNING: -e needs -E or -F $ sudo update-initramfs -u update-initramfs: Generating /boot/initrd.img-6.12.107+deb13-amd64 Can the above warning be ignored?
* Still mid term, we probably want to blacklist SPD probing explicitly for your motherboard (we'll need to know the contents of /sys/devices/virtual/dmi/id/board_vendor and /sys/devices/virtual/dmi/id/board_name on your system). Maybe this can be implemented as an empty entry in mux_dmi_table (as in, we know the board requires multiplexing, but we don't know yet to implement it on that board).
Here we go: $ cat /sys/devices/virtual/dmi/id/board_vendor ASUSTeK COMPUTER INC. $ cat /sys/devices/virtual/dmi/id/board_name WS C422 PRO_SE
* Long term, we need the hardware vendor to provide technical information about the board so that we can implement SMBus multiplexing support in the i2c-i801 driver (if that's really how things are implemented on your board - that's only a guess from me at this point). Asus provided information about their Z8 series long ago and I was able to add support for it back then. It would be wonderful if they could provide similar information about the WS C422 PRO/SE so that a kernel developer can add support.
The user manuals for the board lie at https://www.asus.com/de/motherboards-components/motherboards/workstation/ws-c422-pro-se/helpdesk_manual?model2Name=WS-C422-PRO-SE . As for anything deeper, it would be better if you, as a developer, contacted them directly. (In fact, the last time I actually succeeded in issuing a ticket was a long time ago, before the warranty ran out.) An ASUS support contact form lies at https://www.asus.com/support/product/contactus/services/questionform .

