The upstream project is already dead. Here a quote from the maintainer
{Saturday, October 26, 2013} [21:14:27] <Auria> I don't really have
time/interest anymore to properly develop wxMupen64Plus, unfortunately.
It wasn't working since a while with the mupen64plus version in debian and the
author started to to make it incompatible with mupen64plus 2.0 by purpose in
the past by making it mupen64plus 1.99.5 exclusive. It is most likely better to
just close this bug and move on to m64py [1].
I've already saw m64py packages on git.debian.org (server seems to be down
right now) and it only needs pysdl2 packaged in Debian.
[1] http://bugs.debian.org/678947
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