Is this the common way to do it?

(def sister (assoc brother :name "Cindy"))

If you want to change the value of one key in a map, yes. (In this example it looks weird, of course.)

If you want to create a new map by taking only some values from another map:

user=> (def sister (assoc (select-keys brother [:father :mother]) :name "Mandy"))
#'user/sister

user=> sister
{:name "Mandy", :mother "Mary", :father "John"}


Reading up more on structs, it seems they have base keys that can't be
dissoc.  Is that the main difference then between it and a hash?


Yes. The base keys are reserved as an array, which provides a slight performance enhancement in some situations (no tree-walking). If you have no need for that tiny performance enhancement, you can ignore struct-maps altogether.

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