Is this the common way to do it? (def sister (assoc brother :name "Cindy"))
If you want to change the value of one key in a map, yes. (In this example it looks weird, of course.)
If you want to create a new map by taking only some values from another map:
user=> (def sister (assoc (select-keys brother [:father :mother]) :name "Mandy"))
#'user/sister user=> sister {:name "Mandy", :mother "Mary", :father "John"}
Reading up more on structs, it seems they have base keys that can't be dissoc. Is that the main difference then between it and a hash?
Yes. The base keys are reserved as an array, which provides a slight performance enhancement in some situations (no tree-walking). If you have no need for that tiny performance enhancement, you can ignore struct-maps altogether.
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