> Is there some reason that the Java JIT is not doing this, with the
> original code using defn, as fast as it works when using defmacro?

The macro expands into bytecode within the same Java method, rather  
than a method invocation. Some method blocks are too big to inline,  
and perhaps the JIT doesn't have enough information (or motivation) to  
do so. The JIT compiler will only inline certain hotspots where it  
predicts a benefit. Switching to a macro forces the issue by avoiding  
that runtime analysis altogether.

It's also possible that more type propagation, or elimination of  
boxing (all function parameters are boxed when they cross the function  
boundary) is involved.

I'm sure others will have more to add...

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