https://github.com/thebusby/iota could be useful in your case.


Iota is a Clojure library for handling large text files in memory, and offers 
the following benefits;
* Tuned for Clojure's reducers, letting you reduce over large files quickly.
* Uses Java NIO's mmap() for rapid IO and handling files larger than available 
memory.
* Efficiently stores data as it is represented in the file, and only converts 
to java.lang.String when necessary.
* Offers efficient indexing and caching that emulates Clojure's native vector 
and seq data structures.
* Adjustable buffer sizes for IO and caching, enabling tuning for specific data 
sets.

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