Dear Colleagues,

It is with great sadness that we write to inform you about the passing of 
Professor Noriyoshi Sakabe on October 9, 2025.

Professor Sakabe made pioneering contributions to macromolecular 
crystallography and synchrotron radiation research. In the early 1970s, he 
initiated the insulin project and later collaborated with Professor Dorothy 
Crowfoot Hodgkin’s group at Oxford to successfully determine its structure. 
Subsequently, he achieved a groundbreaking ultra-high-resolution structural 
analysis, detecting electron density corresponding to hydrogen atoms in protein 
crystals something previously thought to be impossible.
Striving for even higher precision, Professor Sakabe developed an innovative 
data collection system for protein crystallography using synchrotron radiation. 
This system, based on a modified Weissenberg camera (known as the “Sakabe 
camera”) and combined with the newly developed Imaging Plates (Fuji Film), 
significantly improved the accuracy and efficiency of diffraction data 
collection at the Photon Factory in Japan. The beamline, under his leadership, 
became one of the world’s most powerful synchrotron beamlines for protein 
crystallography, utilized by researchers globally and yielding numerous 
significant discoveries.
Professor Sakabe was deeply committed to supporting the scientific community, 
and his generosity left a lasting impact on countless researchers worldwide. As 
an inspiring mentor, he was devoted to his students and colleagues, shaping 
generations of scientists.
We deeply mourn his loss and extend our heartfelt condolences to his family, 
friends, and colleagues.

Sincerely,

Atsushi Nakagawa
———————————————————————————
Atsushi NAKAGAWA, Professor, PhD

Japan Synchrotron Radiation Research Institute (JASRI)
1-1-1 Kouto, Sayo-cho, Sayo-gun
Hyogo 679-5198
JAPAN
Tel & Fax : +81-791-58-0950
e-mail : [email protected]

Institute for Protein Research
The University of Osaka
Suita, Osaka 565-0871
JAPAN
Tel & Fax : +81-6-6879-4313
e-mail : [email protected]

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