You and your co-workers are cordially invited to join us .....
"Location of surface waters reveals how antifreeze and ice nucleation proteins work." Peter L. Davies Department of Biomedical and Molecular Sciences Queen’s University, Kingston, Ontario, Canada JULY 30, 13:30(EDT) To register for hybrid attendance: https://bnl.zoomgov.com/meeting/register/8NgwGVixS5a6NLrItnyyEA Abstract: Antifreeze proteins that protect marines fishes from freezing in icy seawater were discovered in the late 1960’s. They function by binding to internal seed ice crystals and preventing their growth. Since then, the variety and roles of ice-binding proteins have increased to include the inhibition of ice recrystallization, ice adhesion, and even ice nucleation. The mechanism by which ice-binding proteins can be freely soluble at millimolar concentrations in water and yet bind irreversibly to the ice – the solid state of water – was a mystery for a long time. But high resolution crystal structures obtained at Brookhaven for several ice-binding proteins showed that they have a clathrate water pattern on their ice-binding sites. We now think that these ice-like waters merge with the quasi-liquid layer of water around an ice crystal and become frozen together at subzero temperatures. Although these proteins are only bound to ice by hydrogen bonds and other weak forces, there are many of them, and almost all would have to break at the same time for the protein to come off the ice. Modeling of ice nucleation protein structures suggests that they resemble much larger versions of ice-binding proteins. In addition, they are also extensively multimerized. Here similar protein surface structures are in place to organize ice-like waters, but in such great numbers that they can nucleate freezing at high sub-zero temperatures up to -2 ºC. ================= Vivian Stojanoff, PhD Education, Training, Outreach User Program p 1(631) 344 8375 e [email protected]<mailto:[email protected]> w https://www.bnl.gov/ps/lifesciences/<https://www.bnl.gov/ps/lsbr/> Address: Center for Biomolecular Structure National Synchrotron Light Source II Building 745 Brookhaven National Laboratory Upton NY 11973 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
BEGIN:VCALENDAR PRODID:-//zoom.us//iCalendar Event//EN VERSION:2.0 CALSCALE:GREGORIAN METHOD:PUBLISH CLASS:PUBLIC BEGIN:VTIMEZONE TZID:America/New_York LAST-MODIFIED:20250410T142247Z TZURL:https://www.tzurl.org/zoneinfo-outlook/America/New_York X-LIC-LOCATION:America/New_York BEGIN:DAYLIGHT TZNAME:EDT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 DTSTART:19700308T020000 RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU END:DAYLIGHT BEGIN:STANDARD TZNAME:EST TZOFFSETFROM:-0400 TZOFFSETTO:-0500 DTSTART:19701101T020000 RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTAMP:20250724T232422Z DTSTART;TZID=America/New_York:20250730T133000 DTEND;TZID=America/New_York:20250730T143000 SUMMARY:CBMS Lecture Series -Davies UID:20250724T232422Z-1602589684@fe80:0:0:0:4dc:2cff:fe3d:6af6eth0 TZID:America/New_York DESCRIPTION:Vivian Stojanoff is inviting you to a scheduled ZoomGov meeti ng.\nJoin ZoomGov Meeting\nhttps://bnl.zoomgov.com/j/1602589684?pwd=Nm3O eIzCblPY6NH9uicSXBrJR4iMDV.1\n\nMeeting ID: 160 258 9684\nPasscode: 6872 03\n\n---\n\nOne tap mobile\n+16692545252\,\,1602589684#\,\,\,\,*687203# US (San Jose)\n+16468287666\,\,1602589684#\,\,\,\,*687203# US (New York )\n\n---\n\nDial by your location\n⢠+1 669 254 5252 US (San Jose)\n⢠+1 646 828 7666 US (New York)\n⢠+1 646 964 1167 US (US Spanish Line)\n⢠+ 1 669 216 1590 US (San Jose)\n⢠+1 415 449 4000 US (US Spanish Line)\n⢠+1 551 285 1373 US (New Jersey)\n\nMeeting ID: 160 258 9684\nPasscode: 6 87203\n\nFind your local number: https://bnl.zoomgov.com/u/aeGFplVOXh\n\ n---\n\nJoin by SIP\n⢠[email protected]\n\n---\n\nJoin by H.32 3\n⢠161.199.138.10 (US West)\n⢠161.199.136.10 (US East)\n\nMeeting ID: 160 258 9684\nPasscode: 687203\n\n LOCATION:https://bnl.zoomgov.com/j/1602589684?pwd=Nm3OeIzCblPY6NH9uicSXBr JR4iMDV.1 BEGIN:VALARM TRIGGER:-PT10M ACTION:DISPLAY DESCRIPTION:Reminder END:VALARM END:VEVENT END:VCALENDAR
