Dear all,
We are recruiting for an exceptional Structural Biologist / Biophysicist with experience in studying structures of protein complexes to join the group of Professor Alessio Ciulli as a Postdoctoral Research Assistant within the Centre for Targeted Protein Degradation (CeTPD) at the University of Dundee.
If you do know of anyone who may be interested, please feel free to point them our way.
This position is part of an academic, multi-disciplinary drug discovery team being formed within the Ciulli group, funded by the Cancer Grand Challenges, within KOODAC (https://cancergrandchallenges.org/teams/koodac).
KOODAC's mission is to discover and develop small molecule drugs that degrade key oncogenic drivers of solid tumours in children, as a novel therapeutic paradigm to treat paediatric cancers. The team will develop two types of degraders - proteolysis targeting chimeras (PROTACs) and molecular glue degraders. Both classes of degraders work by recruiting a ubiquitin E3 ligase to a target protein to induce target's ubiquitination and degradation, leading to cell death. The team will focus on developing degraders for the ALK, DNAJB1::PRKACA, MYCN, EWSR1::FLI1 and PAX3::FOXO1 (or PAX7::FOXO1) oncoproteins, which have been implicated in the development and/or spread of neuroblastoma, fibrolamellar hepatocellular carcinoma, medulloblastoma, Ewings sarcoma and fusion positive rhabdomyosarcoma, respectively, in children.
The successful candidate will characterise the binding of small molecule ligands and PROTACs/molecular glues to their target proteins and E3 ligase components using structural biology techniques (X-ray crystallography and cryo-electron microscopy) and biophysical techniques (FP, TR-FRET, ITC, SPR), to drive the structure- and biophysics guided design of degraders. A particular focus of your work will be on elucidating the structure and binding of degraders' ternary complexes across the project targets, to drive the structure-guided design of degraders. You will work closely with the Senior Lead Scientist and the other PDRAs within the Team in the Ciulli Lab, as well as scientists at our collaborating partners of the KOODAC Team to develop a platform for the discovery, characterisation and development of degraders for the oncoproteins of interest.Link to the advert here https://www.dundee.ac.uk/work-for-us/jobs/uod1951Link to our website here https://sites.dundee.ac.uk/alessio-ciulli/group/koodac-team/
If you do have any questions about the position, please don't hesitate to ask Alessio Ciulli a.ciu...@dundee.ac.uk or Suzanne O'Connor soconnor...@dundee.ac.uk.
All the best,
Michael
Dr. Michael Krummhaar
Member of the KOODAC-Team
Centre for Targeted Protein Degradation
University of Dundee
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