Looks like HEPES to me (or some other sulphonic acid buffer).

The flexibility in the ring could be why there's a gap?

Best wishes

Matthew.
________________________________
From: CCP4 bulletin board <[email protected]> on behalf of John Smith 
<[email protected]>
Sent: 18 June 2025 13:52
To: [email protected] <[email protected]>
Subject: [ccp4bb] Unknown Density

Dear all, we find this interesting density in our map. Any guesses? Thanks for 
your help. Best John To unsubscribe from the CCP4BB list, click the following 
link: https: //www. jiscmail. ac. uk/cgi-bin/WA-JISC. exe?SUBED1=CCP4BB&A=1 
[jiscmail. ac. uk]

Dear all,

we find this interesting density in our map. Any guesses?

Thanks for your help.

Best
John

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