Thank you, Robbie.

I think this analysis is perhaps even more timely given the rumours emanating 
from the White House regarding an executive order covering macromolecules.

Draft text (smuggled out over the US-Canadian border in a dry shipper) as 
follows:

By the authority vested in me as President by the Constitution and the laws of 
the United
States of America, it is hereby ordered:
Section 1: Macromolecules
All amino acids and carbohydrates now to be right wing handed only, all levo 
forms to be outlawed
All proteins containing trans peptide bonds to be banned.
Non-binary amino acid Glycine to be banned.
Proline is not a real amino acid and will be banned immediately.
Phenylalanine looks and sounds a little bit like Fentanyl, banned immediately.
Section 2: Tools for Macromolecular Structure Determination

XDS to be renamed XXDS or XYDS, depending upon the chromosomal make up of the 
user.

PROCHECK. Might have something to do with pronouns. Banned.

Any software tools that attempts to remove bias. Banned.

DIALS? More like DEIALS. Banned.

PDB-REDO. Real winners don't need a second chance. Banned.

<<EOF>>

Truly dark times.

Stay strong,

Dave


--

Dr David C. Briggs CSci MRSB (he/him)

Principal Laboratory Research Scientist

Signalling and Structural Biology Lab

The Francis Crick Institute

London, UK

Working hours: Mon-Fri 0900-1700

==

about.me/david_briggs<https://about.me/david_briggs> | 
OrcID<https://orcid.org/0000-0002-9793-7339> | Google Scholar 
<https://scholar.google.co.uk/citations?user=DRKG5KwAAAAJ>

==

"Would it not be better if one could really 'see' whether molecules...were just 
as experiments suggested?"

– Dorothy Hodgkin

________________________________
From: CCP4 bulletin board <CCP4BB@JISCMAIL.AC.UK> on behalf of Elliot Morgan 
<morgan.method...@gmail.com>
Sent: 01 April 2025 03:33
To: CCP4BB@JISCMAIL.AC.UK <CCP4BB@JISCMAIL.AC.UK>
Subject: Re: [ccp4bb] POTUS and the PDB


External Sender: Use caution.

Nice piece of work! It should be published in the public domain.

Elliot

On Mon, Mar 31, 2025 at 6:07 PM Jurgen Bosch 
<0000dacafb9366f7-dmarc-requ...@jiscmail.ac.uk<mailto:0000dacafb9366f7-dmarc-requ...@jiscmail.ac.uk>>
 wrote:
Well done and an excellent read!
Jürgen

> On Mar 31, 2025, at 5:31 PM, Robbie Joosten 
> <robbie_joos...@hotmail.com<mailto:robbie_joos...@hotmail.com>> wrote:
>
> Dear CCP4bb members,
>
> This month on the CCP4bb we discussed the effect of the current US president 
> on the science and society in quite a lot of detail. I think a fair 
> comparison between this and previous presidents is in order and luckily Gert 
> Vriend performed this analysis for the PDB just before the month ended.
>
> Cheers,
> Robbie
>
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> <POTUS.pdf>

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