Real-Time Cryo-Electron Microscopy to Investigate Enzyme Allostery <https://research.ncl.ac.uk/media/sites/researchwebsites/mosmed/mos2_04%20Real-Time%20Cryo-Electron%20Microscopy%20to%20Investigate%20Enzyme%20Allostery.docx>
A 4-year fully-funded PhD position (UK home rate) is available in Wyatt Yue’s lab <https://www.staff.ncl.ac.uk/yuelab/> at Newcastle University (UK), under the MoSMed CDT <https://research.ncl.ac.uk/mosmed/> programme, starting in Sept 2025. This project builds on the lab's track record in studying metabolic enzymes and their allosteric regulation through a combination of structural biology, biophysics, and chemical biology approaches. The PhD candidate will apply cryo-EM <https://www.findaphd.com/common/clickCount.aspx?theid=183080&type=184&DID=5611&url=https%3a%2f%2fwww.nature.com%2farticles%2fs41467-024-47174-y> and complementary methods <https://www.findaphd.com/common/clickCount.aspx?theid=183080&type=184&DID=5611&url=https%3a%2f%2flinkinghub.elsevier.com%2fretrieve%2fpii%2fS0300-9084(21)00009-2> to chart the conformational dynamics of the human MTHFR enzyme implicated in cancer and neurological disorders. Details of the project as well as instructions on how to apply can be found here <https://www.findaphd.com/phds/project/phd-studentship-real-time-cryo-electron-microscopy-to-investigate-enzyme-allostery/?p183080>. Deadline for applications: 30th March 2025. Enquiries on the project can be emailed to wyatt....@newcastle.ac.uk and thomas.mccor...@newcastle.ac.uk *Prof Wyatt Yue* Professor of Structural Biology Biosciences Institute Faculty of Medical Sciences Newcastle University NE2 4HH Group: www.staff.ncl.ac.uk/yuelab/ Profile: wyattyue.github.io <https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwyattyue.github.io%2F&data=05%7C01%7Cwyatt.yue%40newcastle.ac.uk%7C1055bcc2db874f2422e208db15b5e08a%7C9c5012c9b61644c2a91766814fbe3e87%7C1%7C0%7C638127643116472564%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=Gha93%2B44igl%2BE9GGvPTc%2BGbshX%2F3coCLAMWZ1JuqpfM%3D&reserved=0> ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
