Dear Colleagues,

  The Phenix team is hiring! We are looking for talented postdoctoral 
candidates to join the group in Berkeley. Please see the details below, and 
feel free to pass on to anyone you think might be interested.

  To access the job posting directly: 
https://jobs.lbl.gov/jobs/computational-postdoctoral-fellow-6893 

  Cheers,       
        Paul

Berkeley Lab’s (LBNL) Molecular Biophysics and Integrated Bioimaging Division 
(MBIB) has an opening for a Postdoctoral Fellow to develop new computational 
methods for the structure determination and refinement of protein structures 
using the PHENIX software system.
 
In this exciting role, you will work under the direction of the Deputy Director 
for this project with primary responsibilities including the development and 
implementation of numerical methods and new computational protocols, including 
the application of machine learning methods. The goals of the role include the 
development of automated pipelines for data analysis, structure completion and 
model validation.
 
The Phenix software is used worldwide for the determination of atomic 
structures using X-ray and neutron crystallography and cryo-electron 
microscopy. The software is developed as part of an international collaboration 
supported by the National Institutes of Health and the Phenix Industrial 
Consortium. This will require the organization of results for presentation and 
viewing by project team members, the wider scientific community, and preparing 
results for publication in scientific journals.
 
This position has an earliest start date of February 3, 2025.
 
What You Will Do:

Develop and implement computational algorithms for structure determination 
using crystallography and cryo-electron microscopy including:
Improved methods for the optimization and completion of models
Automated pipelines for data analysis, structure completion, and model 
validation
Apply machine learning methods to problems in crystallography and cryo-electron 
microscopy.
Develop and test new components of the PHENIX software system in collaboration 
with others.
Document software developments.
Collaborate with other researchers in the PHENIX program.
Summarize research results, publish them in peer-reviewed journals, and 
contribute to scientific research papers and reports.
Contribute to discussions on the determination of future directions.
Attend group meetings or conferences/workshops, present status reports, and 
scientific findings as appropriate.
Keep accurate and detailed research notes.
 
What is Required:

A recent Ph.D. (within the last 1-2 years) in Computational Crystallography, 
Computational Cryo-Electron Microscopy, Computational Biology, Bioinformatics, 
Computational Chemistry or a closely related field.
Demonstrated experience in developing computational algorithms for solving 
problems.
Demonstrated experience with computational methods development.
Publications in macromolecular crystallography, cryo-electron microscopy or 
closely related fields.
Good programming and mathematical skills, including familiarity with Python and 
other software development tools.
Strong organizational skills including experience maintaining detailed and 
accurate records of experiment results and analyzed data.
Excellent oral and written communication skills including experience 
organizing/presenting technical reports.
Demonstrated interpersonal skills including experience conducting experiments 
independently and collaborating with a diverse interdisciplinary research team.
 
Desired Qualifications:

Experience with machine learning methods, programming with C++, or equivalent 
object-oriented programming languages.
Experience with the practical aspects of crystallography and/or cryo-electron 
microscopy.
Familiarity with macromolecular structure or computational chemistry.


--
Paul Adams (he/him/his)
Associate Laboratory Director for Biosciences, LBL 
(https://biosciences.lbl.gov) 
Principal Investigator, Computational Crystallography Initiative, LBL 
(http://cci.lbl.gov) 
Vice President for Technology, the Joint BioEnergy Institute 
(http://www.jbei.org) 
Principal Investigator, ALS-ENABLE, Advanced Light Source 
(http://als-enable.lbl.gov) 
Laboratory Research Manager, ENIGMA Science Focus Area (http://enigma.lbl.gov) 
Adjunct Professor, Department of Bioengineering, UC Berkeley 
(http://bioeng.berkeley.edu) 
Member of the Graduate Group in Comparative Biochemistry, UC Berkeley 
(http://compbiochem.berkeley.edu) 

Building 91, Room 410
Building 978, Room 4126
Tel: 1-510-486-4225
http://cci.lbl.gov/paul 
ORCID: 0000-0001-9333-8219

Lawrence Berkeley Laboratory
1 Cyclotron Road
BLDG 91R0183
Berkeley, CA 94720, USA.

Executive Assistant: Michael Espinosa [ meespin...@lbl.gov ][ 1-510-333-6788 ]
Phenix Consortium: Ashley Dawn [ ashleyd...@lbl.gov ][ 1-510-486-5455 ]
--


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