Hi,

We are starting an LCP crystallisation project with a client GPCR fusion 
protein soon.

Can anyone recommend a purchasable GPCR fusion protein that crystallises well 
in LCP and doesn't cost too much, that we can use as a positive control for the 
LCP setup process?

Would also be good to hear community thoughts re the best screens to try 
(besides MemMeso) and any tips for optimizing LCP hits aside from simple grid 
screening.

Thanks for your help, take care, Charlie.



Charlie Nichols
Research Leader | Structural Biology, Biophysics and Protein Science (SBBP)
Small Molecule Drug Discovery | Charles River
Chesterford Research Park, CB10 1XL, United Kingdom


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