Postdoctoral fellowship in Lindkvist lab at Lund University, Sweden

Aquaporins in health and pathology

A highly motivated postdoctoral scientist is sought to work on a project 
designed to extend our understanding of the molecular basis of aquaporins 
(AQPs).
AQPs are evolutionary conserved transmembrane proteins that are responsible for 
water and glycerol regulation in the human body, but also in many other 
organisms. Besides solute transport, AQPs have been shown to be involved in 
cellular signaling, cell migration, and cell-cell adhesion. For instance, AQPs 
are the main glycerol channel in the endocrine pancreas, mediating rapid flux 
of glycerol in β-cells and ultimately insulin secretion. Interestingly, it was 
also recently reported that AQPs in fruit flies have a central role in 
metabolism. The overall goal of the project is to study the structure of 
aquaporins using single particle cryo-EM and combine that with functional 
studies at the cellular level to resolve its mechanism of action. In addition, 
AQPs are therapeutic targets, thus the project will also include the 
development of putative AQP blockers, that can be used for treating diseases 
and/or to selectively kill insects expressing aquaporins.  The project will 
have good access to state-of-the-art facilities within the medical, natural 
science and engineering faculties, as well as being located in close proximity 
to the nearby MAX IV synchrotron where also the Lund cryo-EM facility is 
situated.

Please, use the link below and follow the instructions to apply.
Postdoctoral fellowship: Aquaporins in health and 
pathology<https://lu.varbi.com/en/what:job/jobID:779646/type:job/where:4/apply:1>

A few relevant publications from Lindkvist laboratory

Molecular basis for human aquaporin inhibition
Huang P, Åbacka H, Wilson CJ, Wind ML, Rűtzler M, Hagström-Andersson A, Gourdon 
P, de Groot BL, Venskutonytė R, Lindkvist-Petersson K.
Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2319682121. doi: 
10.1073/pnas.2319682121.

SMS121, a new inhibitor of CD36, impairs fatty acid uptake and viability of 
acute myeloid leukemia
Åbacka H, Masoni S, Poli G, Huang P, Gusso F, Granchi C, Minutolo F, Tuccinardi 
T, Hagström-Andersson AK, Lindkvist-Petersson K.
Sci Rep. 2024 Apr 20;14(1):9104. doi: 10.1038/s41598-024-58689-1.

Cryo-EM structure supports a role of AQP7 as a junction protein.
Huang P, Venskutonytė R Prasad RB, Ardalani H, de Maré SW, Fan X, Li P, Spégel 
P, Yan N, Gourdon P, Artner I, Lindkvist-Petersson K.
Nature Commun. 2023 Feb 3;14(1):600. doi: 10.1038/s41467-023-36272-y

Minimum requirements are:
Candidate needs to have a maximum 8 years after a doctoral degree (PhD), as 
required by the project Grant Agreement signed with the European Commission, at 
least one original publication in a peer-reviewed journal, a background in the 
relevant methods, a complete application package submitted through the AMBER 
portal (including CV and detailed research plan), and finally, strict 
compliance with the MSCA mobility rule that the researcher must not have 
resided or carried out his/her main activity (work, studies, etc.) in the host 
organisation's country for more than twelve months in the three years 
immediately prior to the call deadline.

The employment also requires:
Undergraduate and doctoral degrees in chemistry, biological sciences or other 
relevant fields of science. Basic knowledge of protein expression and 
purification. Basic knowledge in structural biology, preferably experience with 
single particle cryo-EM. Ability to develop and conduct good quality research. 
Demonstration of motivation and ability to work independently and as part of a 
team.

Meritorious for the employment
Ability to perform basic programming tasks expected for routine data handling 
and interpretation. Ability to clearly formulate scientific results and to 
prepare reports as needed/demanded. Evidence of interpersonal skills befitting 
a researcher working in a highly interactive and collaborative environment. 
Demonstration of experience/competence beyond basic understanding of techniques 
mentioned in previous section
Consideration will also be given to good collaboration skills, drive and 
independence, as well as how the applicant, through his experience and 
competence, is judged to complement and strengthen ongoing research within the 
department and the AMBER program, as well as project partner laboratories and 
how they should contribute to its future development.




*******************************************************
Professor Karin Lindkvist
Experimental Medical Science
Medical Structural Biology
Lund University
BMC C13
221 84 Lund, Sweden

Tel: +46 2228041
Tel (mobile): +46 734222786
Email: karin.lindkv...@med.lu.se<mailto:karin.lindkv...@med.lu.se>

LINXS - Institute of Advanced Neutron and X-ray Science
Scheelevägen 19
SE-223 70 Lund
Sweden

Home page: http://www.linxs.se/
Lund university internal post: Hämtställe 37

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