Postdoctoral fellowship in Lindkvist lab at Lund University, Sweden Aquaporins in health and pathology
A highly motivated postdoctoral scientist is sought to work on a project designed to extend our understanding of the molecular basis of aquaporins (AQPs). AQPs are evolutionary conserved transmembrane proteins that are responsible for water and glycerol regulation in the human body, but also in many other organisms. Besides solute transport, AQPs have been shown to be involved in cellular signaling, cell migration, and cell-cell adhesion. For instance, AQPs are the main glycerol channel in the endocrine pancreas, mediating rapid flux of glycerol in β-cells and ultimately insulin secretion. Interestingly, it was also recently reported that AQPs in fruit flies have a central role in metabolism. The overall goal of the project is to study the structure of aquaporins using single particle cryo-EM and combine that with functional studies at the cellular level to resolve its mechanism of action. In addition, AQPs are therapeutic targets, thus the project will also include the development of putative AQP blockers, that can be used for treating diseases and/or to selectively kill insects expressing aquaporins. The project will have good access to state-of-the-art facilities within the medical, natural science and engineering faculties, as well as being located in close proximity to the nearby MAX IV synchrotron where also the Lund cryo-EM facility is situated. Please, use the link below and follow the instructions to apply. Postdoctoral fellowship: Aquaporins in health and pathology<https://lu.varbi.com/en/what:job/jobID:779646/type:job/where:4/apply:1> A few relevant publications from Lindkvist laboratory Molecular basis for human aquaporin inhibition Huang P, Åbacka H, Wilson CJ, Wind ML, Rűtzler M, Hagström-Andersson A, Gourdon P, de Groot BL, Venskutonytė R, Lindkvist-Petersson K. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2319682121. doi: 10.1073/pnas.2319682121. SMS121, a new inhibitor of CD36, impairs fatty acid uptake and viability of acute myeloid leukemia Åbacka H, Masoni S, Poli G, Huang P, Gusso F, Granchi C, Minutolo F, Tuccinardi T, Hagström-Andersson AK, Lindkvist-Petersson K. Sci Rep. 2024 Apr 20;14(1):9104. doi: 10.1038/s41598-024-58689-1. Cryo-EM structure supports a role of AQP7 as a junction protein. Huang P, Venskutonytė R Prasad RB, Ardalani H, de Maré SW, Fan X, Li P, Spégel P, Yan N, Gourdon P, Artner I, Lindkvist-Petersson K. Nature Commun. 2023 Feb 3;14(1):600. doi: 10.1038/s41467-023-36272-y Minimum requirements are: Candidate needs to have a maximum 8 years after a doctoral degree (PhD), as required by the project Grant Agreement signed with the European Commission, at least one original publication in a peer-reviewed journal, a background in the relevant methods, a complete application package submitted through the AMBER portal (including CV and detailed research plan), and finally, strict compliance with the MSCA mobility rule that the researcher must not have resided or carried out his/her main activity (work, studies, etc.) in the host organisation's country for more than twelve months in the three years immediately prior to the call deadline. The employment also requires: Undergraduate and doctoral degrees in chemistry, biological sciences or other relevant fields of science. Basic knowledge of protein expression and purification. Basic knowledge in structural biology, preferably experience with single particle cryo-EM. Ability to develop and conduct good quality research. Demonstration of motivation and ability to work independently and as part of a team. Meritorious for the employment Ability to perform basic programming tasks expected for routine data handling and interpretation. Ability to clearly formulate scientific results and to prepare reports as needed/demanded. Evidence of interpersonal skills befitting a researcher working in a highly interactive and collaborative environment. Demonstration of experience/competence beyond basic understanding of techniques mentioned in previous section Consideration will also be given to good collaboration skills, drive and independence, as well as how the applicant, through his experience and competence, is judged to complement and strengthen ongoing research within the department and the AMBER program, as well as project partner laboratories and how they should contribute to its future development. ******************************************************* Professor Karin Lindkvist Experimental Medical Science Medical Structural Biology Lund University BMC C13 221 84 Lund, Sweden Tel: +46 2228041 Tel (mobile): +46 734222786 Email: karin.lindkv...@med.lu.se<mailto:karin.lindkv...@med.lu.se> LINXS - Institute of Advanced Neutron and X-ray Science Scheelevägen 19 SE-223 70 Lund Sweden Home page: http://www.linxs.se/ Lund university internal post: Hämtställe 37 [cid:image001.png@01DB6822.21A21A10] ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
