ARES PRIVATE This is terrific. Many thanks Derek. Yes indeed this is what we are looking for
chandra ________________________________ From: Derek Logan <derek.lo...@biochemistry.lu.se> Sent: Monday, January 13, 2025 4:36 AM To: Chandra Verma <chan...@bii.a-star.edu.sg> Cc: CCP4BB@jiscmail.ac.uk <CCP4BB@jiscmail.ac.uk> Subject: Re: [ccp4bb] Help please CAUTION: External email. Exercise caution with links and attachments. Hi Chandra, If I understand correctly, you are looking for structures in which two ATP molecules have been seen to interact directly with each other. This has been observed several times in the ATP-cone domains of the enzyme ribonucleotide reductase (RNR) and its associated transcription factor NrdR, both for ATP and dATP. NrdR even binds ATP and dATP simultaneously adjacent to each other. The possibility to form dimers of these ATP-cone domains in the presence of dATP is key to the oligomerisation that results in enzyme inhibition. RNR complexes with 2x dATP: 8P2C, 8P28, 5OLK, 5IM3 RNR complexes with 2x ATP: 8VHN, 8VHP, 8P23, 7AGJ NrdR complex with 2x ATP: 7P37 NrdR complexes with ATP and dATP: 7P3F, 7P3Q Apologies to anyone whose structures I inadvertently missed! /Derek _____________________________________________________ Derek Logan Professor | Biochemistry and Structural Biology Centre for Molecular Protein Science Lund University, Box 124, 221 00 Lund, Sweden www.cmps.lu.se On 10 Jan 2025, at 02:12, Chandra Verma <000064fcc5b1f9c3-dmarc-requ...@jiscmail.ac.uk> wrote: ARES PRIVATE Are there examples where anyone has seen two ATP molecules interacting with each other in the same protein structure and this dimeric state is needed for %function (ie they should not have crystallized by chance due to crystallization conditions). Many thanks and a happy new year chandra This e-mail and any attachments are only for the use of the intended recipient and may contain material that is confidential, privileged and/or protected by the Official Secrets Act. If you are not the intended recipient, please delete it or notify the sender immediately. Please do not copy or use it for any purpose or disclose the contents to any other person. ________________________________ To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
