The team “Structural Biology of Molecular Machines” at the IGBMC in Strasbourg, 
France, is looking for an enthusiastic and highly motivated PhD student. One of 
the main research axis in the group is the dynein motor protein, a complex and 
fascinating molecular machine involved in essential cellular processes like 
mitosis, organelle positioning and the beating of cilia. The aim of the 
proposed project is to investigate the molecular mechanism of dynein by 
high-resolution cryoEM. Complementary functional studies will be carried out as 
well. Preliminary data to demonstrate project feasibility is available.

Applicants should possess a Master’s or Bachelor’s degree in the life sciences, 
or a related discipline. The applicant should have experience in molecular 
biology as well as protein expression and purification. Experience in protein 
expression in insect cells and/or yeast would be considered an advantage. 
Training in cryoEM will be provided. English language skills, the ability to 
work in a team, initiative, flexibility as well as good organizational and 
learning skills are required.

The IGBMC is one of the leading biomedical research institutions in Europe with 
cutting-edge cryo-EM facilities including two Titan Krios electron microscopes 
as well as a Glacios screening microscope.

Applicants should send a CV, a one-page summary of their research experience 
and contact details for two referees to Helgo Schmidt on schmi...@igbmc.fr

The starting date is flexible.

Selected publications:
Busselez J, Koenig G, Sosnowski P, Klos T, Gizardin-Fredon H, Cianferani S, 
Dominique C, Henry Y, Anthony H, Schmidt H (2024) “Remodelling of Rea1 linker 
domain drives the removal of assembly factors from pre-ribosomal particles.” 
Nature Communications: doi: 10.1038/s41467-024-54698-w

Fagiewicz R, Crucifix C., Klos T, Deville C., Kieffer B, Nominé Y, Busselez J., 
Rossolillo P and Schmidt H (2022)"In vitro characterization of the full-length 
human dynein-1 cargo adaptor BicD2", Structure: 30:1470-1478

Sosnowski P., Urnavicius L., Boland A., Fagiewicz R., Busselez J.,  Papai G. 
and Schmidt H (2018) "The CryoEM structure of the Saccharomyces cerevisiae 
ribosome maturation factor Rea1." eLife: https://doi.org/10.7554/eLife.39163

Schmidt H (2015) “Dynein motors: How AAA+ ring opening and closing coordinates 
microtubule binding and linker movement.” Bioessays: 37: 532-543.

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