I should clarify. I am mostly concerned about the electron density map. I want to make sure that I can most closely compare the maps from two different quality structures, rather than the datasets themselves via CC1/2 or other metrics. This is more so for interpreting structural changes.
For example, if there is sparse density for some particular thing indicating partial occupancy, how can I compare those two maps. So for low-resolution datasets, maybe there is less density but is that because of data quality or because in that dataset there is a lower occupancy through some meaningful structural change (compared to higher resolution/better data)? On Fri, 14 Jun 2024 at 14:16, Matt McLeod <mjmcleo...@gmail.com> wrote: > Hi all, > > I am wondering what the best practice is to compare datasets that are of > the same protein but different quality, for instance 2 vs. 3 A. > > I know that truncating the structures to the same resolution bin is > alright, but the data quality in the lower resolution bins are also not the > same. Is there a way to "inject" noise into the data such that the bins > are more similar? > > These datasets cannot be recollected at higher resolution since they are > collected at increasingly high pressure, and the resolution change is > anticorrelated with the pressure; no way to get around crystal stability. > > Any suggestions are appreciated, > Matt > > ######################################################################## > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 > > This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a > mailing list hosted by www.jiscmail.ac.uk, terms & conditions are > available at https://www.jiscmail.ac.uk/policyandsecurity/ > -- *Matthew Jordan McLeod, PhD* *Post-Doctoral Fellow - Cornell University* ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
