Dear all, Our next online industry talk is by Brian Bender of Sosei Heptares on 27 March 2024 at 14:00 UK time. Registration is free but required. Details and registration can be found at https://www.ccpbiosim.ac.uk/soseiheptares2024.
Title: "Applications of AlphaFold and Generative Molecular Design for GPCR SBDD" Abstract: Methodologies for structure prediction and molecule design are advancing at a rapid pace. Staying on top of recent developments requires testing them to understand if they are truly useful for prospective research. In this talk, we will explore the uses of AlphaFold and generative molecular design in the context of drug discovery at a class of membrane proteins known as G protein-coupled receptors. Through the use of retrospective studies, we demonstrate the possibilities and limitations of these technologies. For the limitations that do exist, we will show how we and others in the field are working to overcome these challenges. Both AlphaFold and generative molecular design are powerful methods but require attention to detail to be useful in active drug discovery programs. Please feel free to share this with anyone who might be interested. Best wishes, Sarah ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
